PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma
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منابع مشابه
PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma
Conjunctival melanoma (CM) is an infrequent but potentially lethal malignancy, with limited therapeutic options for metastases. Recent inhibitors of the interaction of programmed cell death protein 1 (PD-1) and its ligand PD-L1 are associated with good clinical responses in many malignancies. To investigate the therapeutic potential of targeting the PD-1/PD-L1 axis in CM, we analyzed the expres...
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Upon analysis of 636 primary breast carcinoma patient samples, we have found that programmed cell death ligand 1 (PD-L1) mRNA expression is associated with tumor-infiltrating lymphocytes (TILs). Furthermore, PD-L1 expression and elevated TILs were associated with longer recurrence-free survival. Thus, our findings indicate that PD-L1 is prognostic in breast cancer and suggests a functional link...
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PURPOSE To evaluate the expression of tumor PD-L1 and changes in tumor-infiltrating lymphocyte (TIL) populations in patients with metastatic melanoma treated with targeted MAPK inhibitors. EXPERIMENTAL DESIGN Ninety-three tumors were analyzed from 40 patients treated with a BRAF inhibitor alone (BRAFi; n = 28) or combination of BRAF and MEK inhibitors (Combi; n = 12). Tumors were excised befo...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.18039